Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fgf8  fibroblast growth factor 8   (Synonyms: Aigf, Fgf-8)
Results	Reference
1	J:81795 Barrow JR, Thomas KR, Boussadia-Zahui O, Moore R, Kemler R, Capecchi MR, McMahon AP, Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev. 2003 Feb 1;17(3):394-409
1*	J:83881 Bell SM, Schreiner CM, Hess KA, Anderson KP, Scott WJ, Asymmetric limb malformations in a new transgene insertional mutant, footless. Mech Dev. 2003 May;120(5):597-605
1*	J:86196 Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ, Sp8 is crucial for limb outgrowth and neuropore closure. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12195-200
1	J:144933 Benazet JD, Bischofberger M, Tiecke E, Goncalves A, Martin JF, Zuniga A, Naef F, Zeller R, A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning. Science. 2009 Feb 20;323(5917):1050-3
1	J:158689 Bouldin CM, Gritli-Linde A, Ahn S, Harfe BD, Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5489-94
1	J:100575 Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP, Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell. 2005 Aug;9(2):283-92
1*	J:49808 Crackower MA, Motoyama J, Tsui LC, Defect in the maintenance of the apical ectodermal ridge in the Dactylaplasia mouse. Dev Biol. 1998 Sep 1;201(1):78-89
1	J:167534 Cui C, Chatterjee B, Francis D, Yu Q, SanAgustin JT, Francis R, Tansey T, Henry C, Wang B, Lemley B, Pazour GJ, Lo CW, Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech. 2011 Jan;4(1):43-56
1*	J:45301 Cygan JA, Johnson RL, McMahon AP, Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997 Dec;124(24):5021-32
1	J:90261 Dupe V, Matt N, Garnier JM, Chambon P, Mark M, Ghyselinck NB, A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14036-41
1	J:127326 Elsaid AF, Delot EC, Collins MD, Differential perturbation of the Fgf/Erk1/2 and Shh pathways in the C57BL/6N and SWV embryonic limb buds after mid-gestational cadmium chloride administration. Mol Genet Metab. 2007 Nov;92(3):258-70
1*	J:96841 Gong SG, Gong TW, Shum L, Identification of markers of the midface. J Dent Res. 2005 Jan;84(1):69-72
1*	J:50311 Hanks MC, Loomis CA, Harris E, Tong CX, Anson-Cartwright L, Auerbach A, Joyner A, Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development. Development. 1998 Nov;125(22):4521-30
1*	J:30345 Haramis AG, Brown JM, Zeller R, The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5' HoxD genes during limb pattern formation. Development. 1995 Dec;121(12):4237-45
1	J:48055 Hecksher-Sorensen J, Hill RE, Lettice L, Double labeling for whole-mount in situ hybridization in mouse. Biotechniques. 1998 Jun;24(6):914-6, 918
1	J:184014 Jin YR, Han XH, Taketo MM, Yoon JK, Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development. Development. 2012 May;139(10):1821-30
1*	J:54206 Jung HS, Oropeza V, Thesleff I, Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae. Mech Dev. 1999 Mar;81(1-2):179-82
1	J:128941 Ko SO, Chung IH, Xu X, Oka S, Zhao H, Cho ES, Deng C, Chai Y, Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol. 2007 Dec 1;312(1):435-47
1*	J:66531 Kraus P, Fraidenraich D, Loomis CA, Some distal limb structures develop in mice lacking Sonic hedgehog signaling. Mech Dev. 2001 Jan;100(1):45-58
1	J:165721 Krawchuk D, Weiner SJ, Chen YT, Lu BC, Costantini F, Behringer RR, Laufer E, Twist1 activity thresholds define multiple functions in limb development. Dev Biol. 2010 Nov 1;347(1):133-46
1*	J:213418 Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC, Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014 Apr 28;29(2):233-40
1*	J:138715 Li WY, Dudas M, Kaartinen V, Signaling through Tgf-beta type I receptor Alk5 is required for upper lip fusion. Mech Dev. 2008 Sep-Oct;125(9-10):874-82
1	J:223057 Lin C, Yin Y, Bell SM, Veith GM, Chen H, Huh SH, Ornitz DM, Ma L, Delineating a conserved genetic cassette promoting outgrowth of body appendages. PLoS Genet. 2013;9(1):e1003231
1*	J:28252 Mahmood R, Bresnick J, Hornbruch A, Mahony C, Morton N, Colquhoun K, Martin P, Lumsden A, Dickson C, Mason I, A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr Biol. 1995 Jul 1;5(7):797-806
1	J:119190 Molotkova N, Molotkov A, Duester G, Role of retinoic acid during forebrain development begins late when Raldh3 generates retinoic acid in the ventral subventricular zone. Dev Biol. 2007 Mar 15;303(2):601-10
1*	J:135997 Nie X, Deng CX, Wang Q, Jiao K, Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev Biol. 2008 Apr 15;316(2):417-30
1	J:74219 Ogino Y, Suzuki K, Haraguchi R, Satoh Y, Dolle P, Yamada G, External genitalia formation: role of fibroblast growth factor, retinoic acid signaling, and distal urethral epithelium. Ann N Y Acad Sci. 2001 Dec;948:13-31
1	J:144308 Ovchinnikov DA, Selever J, Wang Y, Chen YT, Mishina Y, Martin JF, Behringer RR, BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning. Dev Biol. 2006 Jul 1;295(1):103-15
1	J:174195 Saarimaki-Vire J, Alitalo A, Partanen J, Analysis of Cdh22 expression and function in the developing mouse brain. Dev Dyn. 2011 Aug;240(8):1989-2001
1	J:158139 Seifert AW, Yamaguchi T, Cohn MJ, Functional and phylogenetic analysis shows that Fgf8 is a marker of genital induction in mammals but is not required for external genital development. Development. 2009 Aug;136(15):2643-51
1	J:128015 Sheth R, Bastida MF, Ros M, Hoxd and Gli3 interactions modulate digit number in the amniote limb. Dev Biol. 2007 Oct 15;310(2):430-41
1	J:43502 Sidow A, Bulotsky MS, Kerrebrock AW, Bronson RT, Daly MJ, Reeve MP , Hawkins TL , Birren BW , Jaenisch R , Lander ES, Serrate2 is disrupted in the mouse limb-development mutant syndactylism. Nature. 1997 Oct 16;389(6652):722-5
1	J:169050 Soshnikova N, Montavon T, Leleu M, Galjart N, Duboule D, Functional analysis of CTCF during mammalian limb development. Dev Cell. 2010 Dec 14;19(6):819-30
1	J:61886 Sun X, Lewandoski M, Meyers EN, Liu YH, Maxson RE Jr, Martin GR, Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet. 2000 May;25(1):83-6
1	J:157263 Talamillo A, Delgado I, Nakamura T, de-Vega S, Yoshitomi Y, Unda F, Birchmeier W, Yamada Y, Ros MA, Role of Epiprofin, a zinc-finger transcription factor, in limb development. Dev Biol. 2010 Jan 15;337(2):363-74
1*	J:71035 ten Berge D, Brouwer A, Korving J, Reijnen MJ, van Raaij EJ, Verbeek F, Gaffield W, Meijlink F, Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis. Development. 2001 Aug;128(15):2929-38
1	J:101736 Verheyden JM, Lewandoski M, Deng C, Harfe BD, Sun X, Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development. 2005 Oct;132(19):4235-45
1	J:138578 Verheyden JM, Sun X, An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature. 2008 Jul 31;454(7204):638-41
1	J:272581 Wymeersch FJ, Skylaki S, Huang Y, Watson JA, Economou C, Marek-Johnston C, Tomlinson SR, Wilson V, Transcriptionally dynamic progenitor populations organised around a stable niche drive axial patterning. Development. 2019 Jan 2;146(1):dev168161
1	J:46380 Xu X, Weinstein M, Li C, Naski M, Cohen RI, Ornitz DM, Leder P, Deng C, Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development. 1998 Feb;125(4):753-65
1	J:293527 Yakushiji-Kaminatsui N, Kondo T, Hironaka KI, Sharif J, Endo TA, Nakayama M, Masui O, Koseki Y, Kondo K, Ohara O, Vidal M, Morishita Y, Koseki H, Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in the mouse distal forelimb bud. Development. 2018 Oct 11;145(19):dev166348
1	J:83305 Zhang Q, Murcia NS, Chittenden LR, Richards WG, Michaud EJ, Woychik RP, Yoder BK, Loss of the Tg737 protein results in skeletal patterning defects. Dev Dyn. 2003 May;227(1):78-90
1	J:165810 Zhang Z, Sui P, Dong A, Hassell J, Cserjesi P, Chen YT, Behringer RR, Sun X, Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb. Development. 2010 Oct;137(20):3417-26
1	J:219584 Zhulyn O, Hui CC, Sufu and Kif7 in limb patterning and development. Dev Dyn. 2015 Mar;244(3):468-78